Position(s): Professor.

", "Functional analysis of conserved histidines in choline acetyltransferase by site-directed mutagenesis. ", Sarada, B.; Thiele, D.; Dang, T.; Lee, J.; Safavia, A.; Hersh, LB ; Cottam, GL, "Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular beta-endorphin endopeptidase (IDE/gamma-EpGE). Director of Natural Resources and Environmental Science … ", Miller, BC ; Thiele, DL ; Hersh, LB ; Cottam, GL, "Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells. ", "Reaction of malate thiokinase with methoxycarbonyl-CoA disulfide. Pete Comparoni | UK Photo.

I could not think of any other professor who does so much for his students while balancing so many other simultaneous responsibilities.”.

", "Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism.

", Liu, Y.; Studzinski, C.; Beckett, T.; Murphy, MP ; Klein, RL ; Hersh, LB, "Circulating neprilysin clears brain amyloid. K-12 Interaction New! ", Thompson, MW ; Govindaswami, M.; Hersh, LB, "Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. ", Horiguchi, A.; Chen, DY ; Goodman OB, Jr ; Zheng, R.; Shen, R.; Guan, H.; Hersh, LB ; Nanus, DM, "Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis. KY 40546-0091, 323 Gluck Equine Research Ctr Lexington,

", "Reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase in Pseudomonas MA: potential regulation between carbon assimilation and energy production. ", Noinaj, N.; Song, ES ; Bhasin, S.; Alper, BJ ; Schmidt, WK ; Hersh, LB ; Rodgers, DW, "Anion activation site of insulin-degrading enzyme.

For your intial semester in Ag and Medical Biotech, please contact Esther Fleming, efleming@uky.edu, the ABT Academic Coordinator or Dr. Lou Hirsch, robert.hirsch@uky.edu. KY 40546-0099, 222 Medical Science Building Lexington, Departments & Units   /   I remember he often used memes and other pop culture references in his lectures to help students learn and to be more relatable to students,” shared student nominator Katelyn Cox. Director of Natural Resources and Environmental Science … ", "An N-methyl glutamate dehydrogenase from Pseudomonas M.A. ", "Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase. GEN 300: GE Crops -- Scourge or Salvatioin? Iijima, H.; Gerard, NP ; Squassoni, C.; Ewig, J.; Face, D.; Drazen, JM ; Kim, YA ; Shriver, B.; Hersh, LB ; Gerard, C. "Exon 16 del: a novel form of human neutral endopeptidase (CALLA). Brain research 515, 1-2 (1990): 117-25.

", "A novel mammalian high-molecular-weight aminopeptidase. KY 40546-0312, S-307D Agricultural Science Center North Lexington, Philanthropy & Alumni ", Niedowicz, DM ; Reeves, VL ; Platt, TL ; Kohler, K.; Beckett, TL ; Powell, DK ; Lee, TL ; Sexton, TR ; Song, ES ; Brewer, LD ; Latimer, CS ; Kraner, SD ; Larson, KL ; Ozcan, S.; Norris, CM ; Hersh, LB ; Porter, NM ; Wilcock, DM ; Murphy, MP, "Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. dave.mcnear@uky.edu.

Plant Pathology DepartmentUniversity of Kentucky201F Plant Science BuildingLexington, KY 40546-0312(859) 257-7445, Students   /   Digital Media Library, PPA 500: Physiology of Plant Health and Disease, ABT 495: Experimental Techniques in Biotechnology.

", "Kinetic studies of the choline acetyltransferase reaction using isotope exchange at equilibrium. "Cholinergic neuronal loss in the globus pallidus of Alzheimer disease patients. Outside of instruction, Lou’s focus is providing effective science outreach to the community and K-12 school districts throughout Kentucky. ", "Analysis of conserved residues of the human puromycin-sensitive aminopeptidase. Dr. Lou Hirsch. ", Bateman RC, Jr ; Kim, YA ; Slaughter, C.; Hersh, LB, "N-bromoacetyl-D-leucylglycine.

robert.hirsch@uky.edu. Stoltze, L.; Schirle, M.; Schwarz, G.; Schröter, C.; Thompson, MW ; Hersh, LB ; Kalbacher, H.; Stevanovic, S.; Rammensee, HG ; Schild, H. "Two new proteases in the MHC class I processing pathway.

", Casey, ML ; Smith, JW ; Nagai, K.; Hersh, LB ; MacDonald, PC, "Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium. ", Armstrong, DM ; Sheffield, R.; Buzsaki, G.; Chen, KS ; Hersh, LB ; Nearing, B.; Gage, FH, "Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats. I. Biochemical and physiologic studies. ", "Characterization of membrane-bound aminopeptidases from rat brain: identification of the enkephalin-degrading aminopeptidase. PI of COBRE for the Center for Molecular Medicine.

Research   /   The UK Alumni Association 2020 Great Teacher Award was recently bestowed upon six University of Kentucky educators. ", Chow, KM ; Ma, Z.; Cai, J.; Pierce, WM ; Hersh, LB, "Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Laura SkillmanAgricultural Communications Services Director131-A Scovell HallLexington, KY 40546-0064859-323-4761lskillma@email.uky.edu, Students   /   ", "The lack of specificity towards salts in the activation of choline acetyltransferase from human placenta. Outside of instruction, Lou’s focus is providing effective science outreach to the community and K-12 school districts throughout Kentucky.

Dr. Ernest Bailey.

", Ojeda, SR ; Costa, ME ; Katz, KH ; Hersh, LB, "Evidence for the existence of substance P in the prepubertal rat ovary.

Hirsch Extension   /  

", Kim, YA ; Shriver, B.; Quay, T.; Hersh, LB, "Analysis of the importance of arginine 102 in neutral endopeptidase (enkephalinase) catalysis.".

", Gilmor, ML ; Erickson, JD ; Varoqui, H.; Hersh, LB ; Bennett, DA ; Cochran, EJ ; Mufson, EJ ; Levey, AI, "Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. ", Quay, T.; Slaughter, C.; Davis, TP ; Merrill, BJ ; Hersh, LB, "Positional effects in the neprilysin (neutral endopeptidase) reaction.

KY 40536-0298, 461 College of Pharmacy Lexington, ", "Preparation, characterization, and coenzymic properties of 5-carba-5-deaza and 1-carba-1-deaza analogs of riboflavin, FMN, and FAD. “Hirsch is an animated, energetic lecturer who always keeps students laughing and learning. ", "Methoxycarbonyl-CoA disulfide: an active site-directed sulfhydryl reagent.

* ", "Enzymes involved in the degradation of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) in bovine brain.

", Wick, MJ ; Buesing, EJ ; Wehling, CA ; Loomis, ZL ; Cool, CD ; Zamora, MR ; Miller, YE ; Colgan, SP ; Hersh, LB ; Voelkel, NF ; Dempsey, EC, "Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease.